Cyclophosphamide therapy in Sweet's syndrome complicating refractory Crohn's disease - Efficacy and mechanism of action

Cyclophosphamide therapy was highly effective in steroid-refractory Crohn's colitis accompanied by Sweet's syndrome for induction of remission. Furthermore, apoptosis of mononuclear cells in the colon mucosa, including CD68+ macrophages as well as CD4+ and CD8+ cells, appears to be a component of the anti-inflammatory effect of cyclophosphamide in Crohn's disease.