کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6100565 1211076 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Anti-TNF therapy induced immune neutropenia in Crohns disease- report of 2 cases and review of literature
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
پیش نمایش صفحه اول مقاله
Anti-TNF therapy induced immune neutropenia in Crohns disease- report of 2 cases and review of literature
چکیده انگلیسی
Transient neutropenia is reported in some patients on biologic therapy. We report two cases of severe neutropenia in patients with Crohn`s disease following treatment with anti-TNF therapy. In both cases neutrophil specific granulocyte autoantibodies were detected during period of neutropenia and disappeared on cessation of anti-TNF therapy. These may indicate that anti-TNF agents may produce autoimmune agranulocytosis by triggering production granulocyte autoantibodies. The long term management strategy for patients with anti-TNF therapy induced autoimmune neutropenia is uncertain.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Crohn's and Colitis - Volume 6, Issue 6, July 2012, Pages 713-716
نویسندگان
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