کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6100974 1211097 2016 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research ArticlePerioperative blood transfusion does not influence recurrence-free and overall survivals after curative resection for hepatocellular carcinoma: A Propensity Score Matching Analysis
ترجمه فارسی عنوان
تحقیق مقاله: انتقال خون پس از عمل جراحی برای کارسینوم سلولی، از انتقال عود مجدد و بازداری کامل برخوردار نیست. تحلیل تطبیقی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
چکیده انگلیسی

Background & AimsWhether perioperative blood transfusions (PBTs) negatively impact oncologic outcomes after curative resection for HCC remains controversial.We aimed to identify the independent predictive factors of PBT for curative resection of hepatocellular carcinoma (HCC), and to investigate the impact of PBT on long-term recurrence and survivals after resection.MethodsOf 1103 patients who underwent curative liver resection for HCC between 1999 and 2010, 285 (25.8%) patients received PBT. Univariable and multivariable regression analyses were used to identify independent predictive factors of PBT. Propensity scores and Cox regression analyses were used to compare the overall survival (OS) and recurrence-free survival (RFS) between patients who did and did not receive PBT.ResultsMultivariable regression analysis revealed that performance status, preoperative hemoglobin, cirrhosis, portal hypertension, tumor rupture, tumor size, macroscopic vascular invasion, and intraoperative blood loss were independent predictive factors of PBT for HCC resection. Propensity score matching analysis created 234 pairs of patients. Before propensity matching, PBT was significantly associated with increased risks of OS (HR: 2.455, 95% CI: 2.077-2.901, p <0.001) and RFS (HR: 2.018, 95% CI: 1.718-2.370, p <0.001) in the entire cohort. After propensity matching, PBT was not significantly associated with increased risks of OS (HR: 1.229, 95% CI: 0.988-1.527, p = 0.063) and RFS (HR: 1.188, 95% CI: 0.960-1.469, p = 0.113). After adjustment for other prognostic variables in the propensity matched cohort, PBT was still found not to be associated with OS and RFS after HCC resection.ConclusionsThe present study identified that PBT did not influence RFS and OS after curative resection of HCC.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Hepatology - Volume 64, Issue 3, March 2016, Pages 583-593
نویسندگان
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