کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6103326 1211127 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Journal of Hepatology Update: Hepatitis CHCV animal models and liver disease
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
پیش نمایش صفحه اول مقاله
Journal of Hepatology Update: Hepatitis CHCV animal models and liver disease
چکیده انگلیسی

SummaryThe development and evaluation of effective therapies and vaccines for the hepatitis C virus (HCV) and the study of its interactions with the mammalian host have been hindered for a long time by the absence of suitable small animal models. Due to the narrow host tropism of HCV, the development of mice that can be robustly engrafted with human hepatocytes was a major breakthrough since they recapitulate the complete HCV life cycle. This model has been useful to investigate many aspects of the HCV life cycle, including antiviral interventions. However, studies of cellular immunity, immunopathogenesis and resulting liver diseases have been hampered by the lack of a small animal model with a functional immune system. In this review, we summarize the evolution of in vivo models for the study of HCV.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Hepatology - Volume 61, Issue 1, Supplement, November 2014, Pages S26-S33
نویسندگان
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