کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6103920 1590326 2014 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ReviewCharacterization of animal models for primary sclerosing cholangitis (PSC)
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
پیش نمایش صفحه اول مقاله
ReviewCharacterization of animal models for primary sclerosing cholangitis (PSC)
چکیده انگلیسی

SummaryPrimary sclerosing cholangitis (PSC) is a chronic cholangiopathy characterized by biliary fibrosis, development of cholestasis and end stage liver disease, high risk of malignancy, and frequent need for liver transplantation. The poor understanding of its pathogenesis is also reflected in the lack of effective medical treatment. Well-characterized animal models are utterly needed to develop novel pathogenetic concepts and study new treatment strategies. Currently there is no consensus on how to evaluate and characterize potential PSC models, which makes direct comparison of experimental results and effective exchange of study material between research groups difficult. The International Primary Sclerosing Cholangitis Study Group (IPSCSG) has therefore summarized these key issues in a position paper proposing standard requirements for the study of animal models of PSC.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Hepatology - Volume 60, Issue 6, June 2014, Pages 1290-1303
نویسندگان
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