کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6104859 1211142 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research ArticleBeyond plasma bilirubin: The effects of phototherapy and albumin on brain bilirubin levels in Gunn rats
ترجمه فارسی عنوان
بیلی روبین بالون پلاسمای خون: اثرات فتوتراپی و آلبومین بر سطوح بیلیروبین مغز در موشهای گن
کلمات کلیدی
هیپربیلیوبینمی غیرقابل انعطاف پذیر، فتوتراپی، آلبومین، مغز، موش گان،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
چکیده انگلیسی

Background & AimsSevere unconjugated hyperbilirubinemia, as occurs in Crigler-Najjar disease and neonatal jaundice, carries the risk of neurotoxicity. This neurotoxicity is related to the increased passage of free bilirubin (UCBfree), the fraction of bilirubin that is not bound to plasma proteins, into the brain. We hypothesized that albumin treatment would lower the UCBfree fraction, and thus decrease bilirubin accumulation in the brain.MethodsWe treated chronic (e.g., as a model for Crigler-Najjar disease) and acute hemolytic (e.g., as a model for neonatal jaundice) moderate hyperbilirubinemic Gunn rats with phototherapy, human serum albumin (HSA) or phototherapy + HSA.ResultsIn the chronic model, adjunct HSA increased the efficacy of phototherapy; it decreased plasma UCBfree and brain bilirubin by 88% and 67%, respectively (p <0.001). In the acute model, adjunct HSA also increased the efficacy of phototherapy; it decreased plasma UCBfree by 76% (p <0.001) and completely prevented the hemolysis-induced deposition of bilirubin in the brain. Phototherapy alone failed to prevent the deposition of bilirubin in the brain during acute hemolytic jaundice.ConclusionsWe showed that adjunct HSA treatment decreases brain bilirubin levels in phototherapy-treated Gunn rats. We hypothesize that HSA decreases these levels by lowering UCBfree in the plasma. Our results support the feasibility of adjunct albumin treatment in patients with Crigler-Najjar disease or neonatal jaundice.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Hepatology - Volume 58, Issue 1, January 2013, Pages 134-140
نویسندگان
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