کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6107478 1211173 2011 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research ArticleDysadherin can enhance tumorigenesis by conferring properties of stem-like cells to hepatocellular carcinoma cells
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
پیش نمایش صفحه اول مقاله
Research ArticleDysadherin can enhance tumorigenesis by conferring properties of stem-like cells to hepatocellular carcinoma cells
چکیده انگلیسی

Background & AimsHepatocellular carcinoma (HCC) is associated with a high potential for metastasis and disease recurrence, even after surgical resection. The cancer stem cell (CSC) hypothesis proposes that CSCs are responsible for chemo-resistance, recurrence, and metastasis. Dysadherin is a prognostic indicator of metastasis and poor survival in many different cancer types. In this study, we investigated the possible link between dysadherin and CSC in HCC.MethodsWe analyzed the functional implications of dysadherin on cancer stemness by modification of the dysadherin gene in HCC cell lines.ResultsThe transfection of dysadherin cDNA into the liver cancer cell line PLC/PRF/5 enhanced the properties of CSCs, including anti-apoptosis, their sphere-forming ability, side population phenotype, and tumor initiation ability in vivo. Furthermore, knockdown of dysadherin in the liver cancer cell line SK-Hep1 suppressed its stem cell-like properties.ConclusionsThese results show that dysadherin give rise to properties of CSC in HCC. Therefore, these findings suggest that dysadherin may be a potential molecular prognostic marker of HCC and may aid in the development of more effective therapies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Hepatology - Volume 54, Issue 1, January 2011, Pages 122-131
نویسندگان
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