Activation of focal adhesion kinase and JNK contributes to the extracellular matrix and cAMP-GEF mediated survival from bile acid induced apoptosis in rat hepatocytes

JNK activation augments apoptosis in hepatocytes plated on PL and LM. Decreased FAK phosphorylation as seen in cells treated with bile acids or attached to PL and LM promotes hepatocyte apoptosis.