کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6108127 | 1211184 | 2011 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Research ArticleSecond hepatic resection for recurrent hepatocellular cancer: A Western experience Research ArticleSecond hepatic resection for recurrent hepatocellular cancer: A Western experience](/preview/png/6108127.png)
Background & AimsRecurrence of hepatocellular cancer after resection is a significant problem. The optimal treatment of patients with intrahepatic recurrence after resection and well-preserved liver function is not clear. We analyzed the outcomes of patients undergoing a second hepatic resection for recurrent hepatocellular cancer at a single Western center.MethodsThe records of all patients undergoing primary hepatic resection for hepatocellular cancer between January 1994 and January 2009 were reviewed. Patients with a single intrahepatic recurrence, Child's A liver function, and platelet count >100,000/μl underwent a second hepatic resection. Clinical data was recorded and analyzed.ResultsOf the 487 patients undergoing primary resection, 221 developed recurrence, and 35 underwent a second hepatic resection. There were no perioperative mortalities. There were 10 deaths during the study period; 5-year overall survival was 67% from second resection. Time to recurrence from primary resection <1 year and gross vascular invasion at second resection were predictors of survival and recurrence. Patients with recurrence >1 year from primary resection and without gross vascular invasion had a 5-year survival of 81%. There were 17 recurrences with a 3-year recurrence rate of 55%.ConclusionsSecond hepatic resection for recurrent hepatocellular cancer is applicable in about 15% of patient with recurrence. The procedure is safe and can achieve excellent results in well-selected patients. Recurrence continues to be a significant problem.
Journal: Journal of Hepatology - Volume 55, Issue 2, August 2011, Pages 346-350