کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
610986 880663 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Biocompatible polypeptide microcapsules via templating mesoporous silica spheres
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی شیمی کلوئیدی و سطحی
پیش نمایش صفحه اول مقاله
Biocompatible polypeptide microcapsules via templating mesoporous silica spheres
چکیده انگلیسی

We reported the stepwise formation of biocompatible poly(l-lysine)/poly(l-glutamic acid) (PLL/PGA) multilayer films on mesoporous silica (MS) spheres via layer-by-layer (LbL) self-assembly technique. In-situ QCM revealed the nonlinear (exponential) growth of PLL/PGA multilayer films at both pH 5.5 and pH 7.0 conditions. ξ-Potential measurements of the multilayer coated particles indicated that the multilayer surface was being charge-overcompensated in each adsorption step, thereby facilitating adsorption of the next oppositely charged polypeptide onto the MS spheres. Hollow polypeptide capsules could be obtained by subsequently removing silica cores in HF solution. By using enzyme-preloaded MS spheres as capsule templates, a general approach was developed for encapsulating enzymes in biocompatible microcapsules with high loading and retained bioactivity. The loading amount for several enzymes with different sizes and their bioactivity after encapsulation were also reported.

Enzyme preloaded mesoporous silica (MS) particles were used as templates for the layer-by-layer deposition of biocompatible polypeptide multilayer films to prepare microcapsules with high active enzyme loading upon subsequently MS template core removal.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Colloid and Interface Science - Volume 333, Issue 1, 1 May 2009, Pages 341–345
نویسندگان
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