کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6115543 | 1215906 | 2016 | 30 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Impact of immune status on the clinical characteristics and treatment outcomes of nocardiosis
ترجمه فارسی عنوان
تأثیر وضعیت ایمنی بر روی ویژگی های بالینی و پیامدهای درمان نوکاردیوز
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروبیولوژی و بیوتکنولوژی کاربردی
چکیده انگلیسی
Nocardiosis occurs in both immunocompromised and immunocompetent patients. We aimed to assess how its characteristics differ depending on patients' immune status. Of a total of 54 patients with culture-proven nocardiosis diagnosed over 13 years, 18 (33%) were immunocompetent. Half of immunocompetent patients had chronic lung disease and were not receiving systemic corticosteroid. There were no significant differences in clinical, radiographic, and microbiologic characteristics, and treatment outcomes according to immune status, except that pulmonary cavitation (47% vs. 8%) and coexisting infections (17% vs. 0%) were more frequent in immunocompromised hosts. Nocardia farcinica, the most commonly identified isolates at the species level (51%), was highly susceptible to trimethoprim-sulfamethoxazole (100%) and highly resistant to ceftriaxone (94%). Nocardiosis should be considered in differential diagnosis of pneumonia, brain abscess, or soft tissue infection that does not respond to conventional antibiotic therapy such as ceftriaxone, regardless of whether the patient is immunocompromised or not.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diagnostic Microbiology and Infectious Disease - Volume 85, Issue 4, August 2016, Pages 482-487
Journal: Diagnostic Microbiology and Infectious Disease - Volume 85, Issue 4, August 2016, Pages 482-487
نویسندگان
Yong Kyun Kim, Heungsup Sung, Jiwon Jung, Shi Nae Yu, Ju Young Lee, Sung-Han Kim, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Sang-Oh Lee, Yong Pil Chong,