کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6115568 | 1215908 | 2015 | 63 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Molecular epidemiology of KPC-2-producing Enterobacteriaceae (non-Klebsiella pneumoniae) isolated from Brazil
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروبیولوژی و بیوتکنولوژی کاربردی
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چکیده انگلیسی
In Brazil, since 2009, there has been an ever increasing widespread of the blaKPC-2 gene, mainly in Klebsiella pneumoniae. This study aims to assess the molecular epidemiology and genetic background of this gene in Enterobacteriaceae (non-K. pneumoniae) species from 9 Brazilian states between 2009 and 2011. Three hundred eighty-seven isolates were analyzed exhibiting nonsusceptibility to carbapenems, in which the blaKPC-2 gene was detected in 21.4%. By disk diffusion and E-test, these isolates exhibited high rates of resistance to most of the antimicrobials tested, including tigecycline (45.6% nonsusceptible) and polymyxin B (16.5%), the most resistant species being Enterobacter aerogenes and Enterobacter cloacae. We found great clonal diversity and a variety of blaKPC-2-carrying plasmids, all of them exhibiting a partial Tn4401 structure. Therefore, this study demonstrates the dissemination of KPC-2 in 9 Enterobacteriaceae species, including species that were not previously described such as Pantoea agglomerans and Providencia stuartii.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diagnostic Microbiology and Infectious Disease - Volume 82, Issue 4, August 2015, Pages 326-330
Journal: Diagnostic Microbiology and Infectious Disease - Volume 82, Issue 4, August 2015, Pages 326-330
نویسندگان
Carolina Padilha Tavares, Polyana Silva Pereira, Elizabeth de Andrade Marques, Celio Jr., Maria da Penha Araújo Herkenhoff de Souza, Robmary de Almeida, Carlene de Fátima Morais Alves, Marise Dutra Asensi, Ana Paula D'Alincourt Carvalho-Assef,