کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6115662 | 1215918 | 2016 | 28 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Infectious cause of death determination using minimally invasive autopsies in developing countries
ترجمه فارسی عنوان
علت عفونت مرگ و میر ناشی از تشنجات مهاجم تهاجمی در کشورهای در حال توسعه
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کلمات کلیدی
مطالعات میکروبیولوژیک، کالبد شکافی مهاجم،
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروبیولوژی و بیوتکنولوژی کاربردی
چکیده انگلیسی
In developing countries, the knowledge of the microorganisms causing fatal infections is critical and could help designing and implementing more effective preventive interventions and treatment guidelines. We aimed to develop and validate protocols for microbiological analysis in post-mortem samples obtained during minimally invasive autopsy (MIA) procedures and to assess their performance. Thirty MIAs performed in adults at Maputo Central Hospital in Southern Mozambique were included in the analysis. Microbiological tests included a universal screening for HIV, hepatitis B and C viruses, Plasmodium falciparum, and bacterial/fungal culture. In addition, a variety of molecular microbiology assays guided by the histological results were performed in blood, cerebrospinal fluid and a variety of tissue samples including liver, lung and central nervous system. The combination of culture-based methods together with molecular microbiological assays led to the identification of 17 out of 19 (89.5%) of the infectious deaths. Microorganisms identified included Mycobacterium tuberculosis, Toxoplasma gondii, Pneumocystis jiroveci, Cryptococcus neoformans, hepatitis B virus, human herpesvirus 8, cytomegalovirus, Streptococcus pneumoniae, Streptococcus dysgalactiae, Ryzopus oryzae, and Acinetobacter baumannii. The combination of classical cultures, serological tests and molecular assays performed in samples obtained through MIA allows the identification of most infectious agents causing death.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diagnostic Microbiology and Infectious Disease - Volume 84, Issue 1, January 2016, Pages 80-86
Journal: Diagnostic Microbiology and Infectious Disease - Volume 84, Issue 1, January 2016, Pages 80-86
نویسندگان
Miguel J. MartÃnez, Sergio Massora, Inácio Mandomando, Esperança Ussene, Dercio Jordao, Lucilia Lovane, Carmen Muñoz-Almagro, Paola Castillo, Alfredo Mayor, Cristina Rodriguez, Miriam Lopez-Villanueva, Mamudo R. Ismail, Carla Carrilho,