کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6116703 | 1216379 | 2014 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Significance of association of HLA-C and HLA-E with psoriatic arthritis
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
Psoriatic arthritis (PsA) is a complex genetic disorder that results from an interplay between multiple genetic and environmental factors. The aim of the study was to assess the significance of the association between the HLA-C and HLA-E allelic groups and PsA. Our results confirm the association between HLA-Câ06 and PsA (OR = 5.16, p < 0.0001). Furthermore, HLA-Câ06-positive patients develop more severe disease (p < 0.01) and more frequently present with polyarticular pattern of PsA (p = 0.08). Additionally our study revealed that the HLA-Câ02 allele was more frequently observed in PsA patients (OR = 5.40, p < 0.0005) and also that the HLA-Eâ01:01 allele was significantly over-represented among HLA-Câ02-negative patients in comparison to healthy individuals (OR = 6.44, p = 0.045). Therefore these results suggest that the HLA-E and HLA-Câ02 molecules may also play an important role in determination immune response contributing to the PsA development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Immunology - Volume 75, Issue 12, December 2014, Pages 1188-1191
Journal: Human Immunology - Volume 75, Issue 12, December 2014, Pages 1188-1191
نویسندگان
Renata Sokolik, Katarzyna GÄbura, Milena Iwaszko, Jerzy Åwierkot, Lucyna Korman, Piotr Wiland, Katarzyna Bogunia-Kubik,