کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6116791 | 1216390 | 2013 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The genetic architecture of 3â²untranslated region of the MICA gene: Polymorphisms and haplotypes
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
In this study, the 3â²untranslated region (3â²UTR) of MHC class I chain-related gene A (MICA) were investigated in 104 healthy, unrelated Han individuals recruited from northern China, using PCR-sequencing method. Nine polymorphic sites were detected, which were in very strong linkage disequilibrium with each other .Seven different MICA 3â²UTR alleles were identified, among which UTR1 predominated (0.6971),followed by UTR2 (0.2356). Twenty-one extended haplotypes incorporating the 3â²UTR and MICA exons 2-5 were observed in this population. Phylogenetic analysis revealed the existence of two MICA lineages, each with multiple subsets. The 2 lineages were primarily linked to UTR1 and UTR2 in the 3â²UTR, respectively. Ewens-Watterson homozygosity statistics at MICA coding and 3â²UTR regions were consistent with neutral expectations. Our data provided for the first time the data of genetic variation in the 3â²UTR of MICA gene in human populations. The findings are valuable for future studies of the mechanisms underlying MICA post-transcriptional regulation, and will inform studies of evolution of the MHC gene complex.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Immunology - Volume 74, Issue 10, October 2013, Pages 1321-1325
Journal: Human Immunology - Volume 74, Issue 10, October 2013, Pages 1321-1325
نویسندگان
Jia Luo, Wei Tian, Xue Xiang Liu, JunLong Yu, LiXin Li, FengHua Pan,