کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6116833 | 1216395 | 2013 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Altered expressions of peripheral CD11c, CD80, CD83 markers and associations of HLA class II allele and haplotypes in self-limiting Hepatitis E infection
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Hepatitis E virus (HEV), the major cause of self limiting viral hepatitis, is associated with a robust humoral, moderate CD4 T cell and CTL response. However, key questions like the probable involvement of HLA class II alleles and peripheral DCs/monocytes in regulating the innate and adaptive immune responses in Hepatitis E remain unanswered. One eighty four self- limiting Hepatitis E patients and 283 anti-HEV negative controls from Western India were studied for the distribution of HLA class II alleles and the frequencies of peripheral CD80, CD83, CD86, HLA-DR and CD11c by PCR SSP method and flow cytometry respectively. Frequency of DRB1â11 allele group was significantly low while haplotypes DRB1â15/DQB1â06 and DRB1â10/DQB1â05 were significantly high in the patient population. CD11c, CD80 and CD83 expressions were high in the patient groups. CD11c expression was positively associated with viral load. CD86 expression was significantly low in the patients having DQB1â06 allele. Association of HLA-DRB1â11 and the emergence of DRB1â15/DQB1â06 and DRB1â10/DQB1â05 as susceptible haplotypes towards HEV infection is being reported for the first time. Positive correlation of CD11c with HEV viral load suggested that increased frequencies of the same might be associated with HEV replication.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Immunology - Volume 74, Issue 3, March 2013, Pages 277-285
Journal: Human Immunology - Volume 74, Issue 3, March 2013, Pages 277-285
نویسندگان
Rumki Das, Sanjay B. Rathod, Kalichamy Alagarasu, Vidya A. Arankalle, Anuradha S. Tripathy,