کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6117578 | 1591752 | 2016 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In vitro activity of artemisone and artemisinin derivatives against extracellular and intracellular Helicobacter pylori
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروبیولوژی و بیوتکنولوژی کاربردی
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چکیده انگلیسی
The in vitro activity of the new artemisinin derivative artemisone as well as other molecules of the same class against Helicobacter pylori and their effects when combined with standard antibiotics were evaluated. Since H.âpylori can be internalised into gastric epithelial cells, the effects of artemisinin, dihydroartemisinin and artemisone against intracellular H.âpylori were also investigated. Bacteriostatic [minimum inhibitory concentration (MIC)] and bactericidal [minimum bactericidal concentration (MBC)] activities were assessed against 24 clinical strains of H.âpylori with different antibiotics susceptibilities. Artemisone showed MIC50 and MIC90 values of 0.25âmg/L and 0.5âmg/L, respectively, and an MBC50 value of 0.5âmg/L. Artemisone was synergistic with amoxicillin in 60% of strains, with clarithromycin in 40% and with metronidazole in 20%. There was no interaction between artemisone and omeprazole or bismuth citrate. Against intracellular H.âpylori, only dihydroartemisinin at 2Ã MIC caused a 1 log10 CFU decrease after 18âh and 24âh of incubation. This is the first demonstration in vitro of the activity of artemisinin derivatives against intracellular H.âpylori and indicates that artemisone has the potential to be efficacious for the treatment of H.âpylori infection, especially in combination with antibiotics.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Antimicrobial Agents - Volume 48, Issue 1, July 2016, Pages 101-105
Journal: International Journal of Antimicrobial Agents - Volume 48, Issue 1, July 2016, Pages 101-105
نویسندگان
Francesca Sisto, Maria Maddalena Scaltrito, Carla Masia, Arianna Bonomi, Valentina Coccè, Giuseppe Marano, Richard K. Haynes, Alessandro Miani, Giampietro Farronato, Donatella Taramelli,