کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6118116 1591808 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Curing bacteria of antibiotic resistance: reverse antibiotics, a novel class of antibiotics in nature
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Curing bacteria of antibiotic resistance: reverse antibiotics, a novel class of antibiotics in nature
چکیده انگلیسی
By screening cultures of soil bacteria, we re-discovered an old antibiotic (nybomycin) as an antibiotic with a novel feature. Nybomycin is active against quinolone-resistant Staphylococcus aureus strains with mutated gyrA genes but not against those with intact gyrA genes against which quinolone antibiotics are effective. Nybomycin-resistant mutant strains were generated from a quinolone-resistant, nybomycin-susceptible, vancomycin-intermediate S. aureus (VISA) strain Mu50. The mutants, occurring at an extremely low rate (<1 × 10−11/generation), were found to have their gyrA genes back-mutated and to have lost quinolone resistance. Here we describe nybomycin as the first member of a novel class of antibiotics designated 'reverse antibiotics'.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Antimicrobial Agents - Volume 39, Issue 6, June 2012, Pages 478-485
نویسندگان
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