کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6118116 | 1591808 | 2012 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Curing bacteria of antibiotic resistance: reverse antibiotics, a novel class of antibiotics in nature
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروبیولوژی و بیوتکنولوژی کاربردی
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چکیده انگلیسی
By screening cultures of soil bacteria, we re-discovered an old antibiotic (nybomycin) as an antibiotic with a novel feature. Nybomycin is active against quinolone-resistant Staphylococcus aureus strains with mutated gyrA genes but not against those with intact gyrA genes against which quinolone antibiotics are effective. Nybomycin-resistant mutant strains were generated from a quinolone-resistant, nybomycin-susceptible, vancomycin-intermediate S. aureus (VISA) strain Mu50. The mutants, occurring at an extremely low rate (<1Â ÃÂ 10â11/generation), were found to have their gyrA genes back-mutated and to have lost quinolone resistance. Here we describe nybomycin as the first member of a novel class of antibiotics designated 'reverse antibiotics'.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Antimicrobial Agents - Volume 39, Issue 6, June 2012, Pages 478-485
Journal: International Journal of Antimicrobial Agents - Volume 39, Issue 6, June 2012, Pages 478-485
نویسندگان
Keiichi Hiramatsu, Masayuki Igarashi, Yuh Morimoto, Tadashi Baba, Maya Umekita, Yuzuru Akamatsu,