کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6156363 | 1598237 | 2016 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hydroxyurea for Treatment of Nephrotic Syndrome Associated With Polycythemia Vera
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کلمات کلیدی
Polycythemia veramyeloproliferative disorder - اختلال میلولپرولیفراتیوKidney biopsy - بیوپسی کلیهnephrotic syndrome - سندرم نفروتیکRenal function - عملکرد کلیهHydroxyurea - هیدروکسی اورهProteinuria - پروتئینوریCase report - گزارش موردیFocal segmental glomerulosclerosis (FSGS) - گلومرول اسکلروز بخش مرکزی (FSGS)
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای کلیوی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Myeloproliferative disorders are a rare cause of focal segmental glomerulosclerosis (FSGS), although the mechanism is unclear. Hydroxyurea is commonly used in these disorders for its cytoreductive properties; however, the effect of this treatment on proteinuria or kidney function remains unclear in cases of myeloproliferative disorder-associated FSGS. We describe the clinical course of a patient with polycythemia vera and nephrotic-range proteinuria, demonstrated to have FSGS on biopsy. The patient had a distant history of granulomatosis with polyangiitis (Wegener's), for which he routinely had his kidney function and proteinuria measured, allowing for early detection of nephrotic syndrome soon after being diagnosed with polycythemia vera. Treatment with hydroxyurea resulted in rapid improvement in proteinuria that correlated with a decrease in hematocrit. This response was replicated 2 additional times when the patient was taken off and then restarted on hydroxyurea therapy. He now maintains a steady dose of hydroxyurea with favorable kidney measures (proteinuria with <1 g/d of protein excretion and serum creatinine of 1.27 mg/dL [corresponding to estimated glomerular filtration rate of 56 mL/min/1.73 m2]). This case suggests that early screening and treatment for myeloproliferative disorder-associated FSGS may lead to improved long-standing kidney function.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: American Journal of Kidney Diseases - Volume 68, Issue 3, September 2016, Pages 465-468
Journal: American Journal of Kidney Diseases - Volume 68, Issue 3, September 2016, Pages 465-468
نویسندگان
Gregory L. MD, MPH, Ivy A. MD, Yi-Bin MD, Robert B. MD, Nina E. MD,