کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6156544 | 1598246 | 2016 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Heat Stress Nephropathy From Exercise-Induced Uric Acid Crystalluria: A Perspective on Mesoamerican Nephropathy
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کلمات کلیدی
Mesoamerican nephropathy (MeN)Tubular injury - آسیب لوله ایCentral America - آمریکای مرکزیUrinary acidification - اسیدی شدن ادرارChronic kidney disease (CKD) - بیماری مزمن کلیه (CKD)Physical exertion - تمرین فیزیکیDehydration - دهیدراسیون، کمآبی بدنRhabdomyolysis - رابدومیولیزEtiology - سببشناسی یا اتیولوژیHypothesis - فرضیهHyperuricemia - هیپریریسمی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای کلیوی
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![عکس صفحه اول مقاله: Heat Stress Nephropathy From Exercise-Induced Uric Acid Crystalluria: A Perspective on Mesoamerican Nephropathy Heat Stress Nephropathy From Exercise-Induced Uric Acid Crystalluria: A Perspective on Mesoamerican Nephropathy](/preview/png/6156544.png)
چکیده انگلیسی
Mesoamerican nephropathy (MeN), an epidemic in Central America, is a chronic kidney disease of unknown cause. In this article, we argue that MeN may be a uric acid disorder. Individuals at risk for developing the disease are primarily male workers exposed to heat stress and physical exertion that predisposes to recurrent water and volume depletion, often accompanied by urinary concentration and acidification. Uric acid is generated during heat stress, in part consequent to nucleotide release from muscles. We hypothesize that working in the sugarcane fields may result in cyclic uricosuria in which uric acid concentrations exceed solubility, leading to the formation of dihydrate urate crystals and local injury. Consistent with this hypothesis, we present pilot data documenting the common presence of urate crystals in the urine of sugarcane workers from El Salvador. High end-of-workday urinary uric acid concentrations were common in a pilot study, particularly if urine pH was corrected to 7. Hyperuricemia may induce glomerular hypertension, whereas the increased urinary uric acid may directly injure renal tubules. Thus, MeN may result from exercise and heat stress associated with dehydration-induced hyperuricemia and uricosuria. Increased hydration with water and salt, urinary alkalinization, reduction in sugary beverage intake, and inhibitors of uric acid synthesis should be tested for disease prevention.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: American Journal of Kidney Diseases - Volume 67, Issue 1, January 2016, Pages 20-30
Journal: American Journal of Kidney Diseases - Volume 67, Issue 1, January 2016, Pages 20-30
نویسندگان
Carlos BS, Ramón MD, Lars MD, Miguel A. PhD, Catharina MD, PhD, Tamara BS, Aurora MD, PhD, Felix MD, Emmanuel R. MD, Marvin A. MD, Ilana MPH, MA, Jason BA, Laura G. PhD, Richard J. MD,