کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6157109 | 1598250 | 2015 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Testing for High-Risk APOL1 Alleles in Potential Living Kidney Donors
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کلمات کلیدی
apolipoprotein L1African American - آمریکاییهای آفریقایی تبار Medical ethics - اخلاق پزشکیGenetic susceptibility - استعداد ژنتیکی یا آسیب پذیری ژنتیکی contraindication - انعقاد قراردادend-stage renal disease (ESRD) - بیماری کلیوی مرحله پایانی (ESRD)Racial difference - تفاوت نژادیRisk stratification - طبقه بندی خطرDonor screening - غربالگری اهدا کنندهKidney failure - نارسایی کلیهRenal transplantation - پیوند کلیهLiving kidney donation - کمک به زندگی کلیه
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای کلیوی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Accurate risk assessment is critical when evaluating potential living kidney donors. High-risk kidney APOL1 variants have been associated with end-stage renal disease of multiple causes among African Americans, though the predictive power of these variants in population-based studies is small. No studies have looked at the effect of high-risk APOL1 alleles on donor outcomes, though few transplantation centers in the United States offer screening for APOL1 among African American donors. Screening all African Americans for high-risk APOL1 alleles may result in the exclusion of many potential donors (â¼13% of African Americans). Such an exclusion may have a large effect on the availability of transplants for African Americans, who are already less likely to undergo transplantation. Nephrologists should be prepared to discuss with potential African American donors the relative increase in risk that is likely conferred by carrying 2 high-risk APOL1 alleles and how additional factors such as environmental exposures (eg, viral infections) and/or other genetic susceptibilities may be required for developing kidney disease. In this Perspective, we review the use of APOL1 testing for risk stratification of potential African American kidney donors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: American Journal of Kidney Diseases - Volume 66, Issue 3, September 2015, Pages 396-401
Journal: American Journal of Kidney Diseases - Volume 66, Issue 3, September 2015, Pages 396-401
نویسندگان
Leonardo V. MD, PhD, Alice M. MD,