کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6160942 | 1249358 | 2016 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Elevated blood pressure is not associated with accelerated glomerular filtration rate decline in the general non-diabetic middle-aged population
ترجمه فارسی عنوان
فشار خون بالا با کاهش سرعت فیلتراسیون گلومرولی در جمعیت متوسط سالمند غیر دیابتی همراه نیست
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کلمات کلیدی
بیماری قلب و عروقی، بیماری مزمن کلیوی، بیش از حد فلفل چاقی،
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای کلیوی
چکیده انگلیسی
Although hypertension is a risk factor for end-stage renal disease, this complication develops in only a minority of hypertensive patients. Whether non-malignant hypertension itself is sufficient to cause reduced glomerular filtration rate (GFR) is unclear. Therefore, we investigated whether elevated blood pressure (BP) was associated with accelerated GFR decline in the general population. The study was based on the Renal Iohexol Clearance Survey in Tromsø 6 (RENIS-T6), which included a representative sample of 1594 individuals aged 50 to 62 years from the general population without baseline diabetes or kidney or cardiovascular disease. GFR was measured as iohexol clearance at baseline and follow-up after a median observation time of 5.6 years. BP was measured according to a standardized procedure. The mean (SD) GFR decline rate was 0.95 (2.23) ml/min/yr. In multivariable adjusted linear mixed regressions with either baseline systolic or diastolic BP as the independent variable, there were no statistically significant associations with GFR decline. Thus, elevated BP is not associated with accelerated mean GFR decline in the general middle-aged population. Hence, additional genetic and environmental factors are probably necessary for elevated BP to develop manifest chronic kidney disease in some individuals.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Kidney International - Volume 90, Issue 2, August 2016, Pages 404-410
Journal: Kidney International - Volume 90, Issue 2, August 2016, Pages 404-410
نویسندگان
Bjørn O. Eriksen, Vidar T.N. Stefansson, Trond G. Jenssen, Ulla D. Mathisen, Jørgen Schei, Marit D. Solbu, Tom Wilsgaard, Toralf Melsom,