کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6161869 | 1249377 | 2015 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Increased circulating sclerostin levels in end-stage renal disease predict biopsy-verified vascular medial calcification and coronary artery calcification
ترجمه فارسی عنوان
افزایش سطح سرمی اسکلروستین در بیماران مبتلا به نارسایی کلیه، پیشآزمون کلسیفیکاس مدیا عروقی و ضایعه عروق کرونر
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کلمات کلیدی
بیماری کلیوی در مرحله پایانی، التهاب بیماری استخوانی معدنی، اسکلرستین کلسیفیکاسیون عروقی،
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای کلیوی
چکیده انگلیسی
Sclerostin, an osteocyte-derived inhibitor of bone formation, is linked to mineral bone disorder. In order to validate its potential as a predictor of vascular calcification, we explored associations of circulating sclerostin with measures of calcification in 89 epigastric artery biopsies from patients with end-stage renal disease. Significantly higher sclerostin levels were found in the serum of patients with epigastric and coronary artery calcification (calcification score 100 or more). In Spearman's rank correlations, sclerostin levels significantly associated with age, intact parathyroid hormone, bone-specific alkaline phosphatase, and percent calcification. Multivariable regression showed that age, male gender, and sclerostin each significantly associated with the presence of medial vascular calcification. Receiver operating characteristic curve analysis showed that sclerostin (AUC 0.68) predicted vascular calcification. Vascular sclerostin mRNA and protein expressions were low or absent, and did not differ between calcified and non-calcified vessels, suggesting that the vasculature is not a major contributor to circulating levels. Thus, high serum sclerostin levels associate with the extent of vascular calcification as evaluated both by coronary artery CT and scoring of epigastric artery calcification. Among circulating biomarkers of mineral bone disorder, only sclerostin predicted vascular calcification.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Kidney International - Volume 88, Issue 6, December 2015, Pages 1356-1364
Journal: Kidney International - Volume 88, Issue 6, December 2015, Pages 1356-1364
نویسندگان
Abdul Rashid Qureshi, Hannes Olauson, Anna Witasp, Mathias Haarhaus, Vincent Brandenburg, Annika Wernerson, Bengt Lindholm, Magnus Söderberg, Lars Wennberg, Louise Nordfors, Jonaz Ripsweden, Peter Barany, Peter Stenvinkel,