کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6162242 | 1249387 | 2015 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Each additional hour of cold ischemia time significantly increases the risk of graft failure and mortality following renal transplantation
ترجمه فارسی عنوان
هر ساعت اضافی زمان ایسکمی سرد، احتمال خطر شکستگی پیوند و مرگ و میر ناشی از پیوند کلیه را به طور قابل توجهی افزایش می دهد
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کلمات کلیدی
زمان سرد ایسکمی، زنده ماندن پیوند کلیه، بقای بیمار،
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای کلیوی
چکیده انگلیسی
Although cold ischemia time has been widely studied in renal transplantation area, there is no consensus on its precise relationship with the transplantation outcomes. To study this, we sampled data from 3839 adult recipients of a first heart-beating deceased donor kidney transplanted between 2000 and 2011 within the French observational multicentric prospective DIVAT cohort. A Cox model was used to assess the relationship between cold ischemia time and death-censored graft survival or patient survival by using piecewise log-linear function. There was a significant proportional increase in the risk of graft failure for each additional hour of cold ischemia time (hazard ratio, 1.013). As an example, a patient who received a kidney with a cold ischemia time of 30Â h presented a risk of graft failure near 40% higher than a patient with a cold ischemia time of 6Â h. Moreover, we found that the risk of death also proportionally increased for each additional hour of cold ischemia time (hazard ratio, 1.018). Thus, every additional hour of cold ischemia time must be taken into account in order to increase graft and patient survival. These findings are of practical clinical interest, as cold ischemia time is among one of the main modifiable pre-transplantation risk factors that can be minimized by improved management of the peri-transplantation period.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Kidney International - Volume 87, Issue 2, February 2015, Pages 343-349
Journal: Kidney International - Volume 87, Issue 2, February 2015, Pages 343-349
نویسندگان
Agnes Debout, Yohann Foucher, Katy Trébern-Launay, Christophe Legendre, Henri Kreis, Georges Mourad, Valérie Garrigue, Emmanuel Morelon, Fanny Buron, Lionel Rostaing, Nassim Kamar, Michèle Kessler, Marc Ladrière, Alexandra Poignas, Amina Blidi,