کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6165123 1250212 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mechanisms of Epithelial Repair and Regeneration After Acute Kidney Injury
ترجمه فارسی عنوان
مکانیسم تعمیر و بازسازی اپیتلیال پس از آسیب حاد کلیه
کلمات کلیدی
آسیب حاد کلیه، بازسازی لوله سلول های لوله ای پروگزیمال،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های کلیوی
چکیده انگلیسی

SummaryAcute kidney injury (AKI) is a common clinical problem and is associated with high mortality rates. It is accepted that after AKI cellular regeneration of the proximal tubule occurs from intrinsic tubule cells. Recently, scattered tubular cells (STCs) were discovered as a novel subpopulation of tubule cells involved in regeneration. STCs have a distinct morphology, unique protein expression profile resembling that of parietal epithelial cells, proliferate more than the remaining proximal tubule cells, and are less susceptible to injuries. In response to AKI, STCs become more numerous, independent of the primary insult (ischemic, acute obstruction, and so forth). STCs can be detected with the highest sensitivity and manipulated by the parietal epithelial cell-specific, doxycycline inducible transgenic mouse line PEC-rtTA. In cell fate tracing experiments it was shown that STCs are not a fixed progenitor population. Rather, STCs arise from any surviving proximal tubule cell. Thus, the STC phenotype is a transient, graded, and specific transcriptional program facilitating tubular regeneration. Understanding this program my open new approaches to prevent and/or treat AKI.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Nephrology - Volume 34, Issue 4, July 2014, Pages 394-403
نویسندگان
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