کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6174154 1599812 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Regression of the inflammatory microenvironment of the peritoneal cavity in women with endometriosis by GnRHa treatment
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Regression of the inflammatory microenvironment of the peritoneal cavity in women with endometriosis by GnRHa treatment
چکیده انگلیسی

ObjectiveTo investigate the effect of gonadotropin-releasing hormone analogues (GnRHa) on the peritoneal fluid microenvironment in women with endometriosis.Study designPeritoneal fluid was collected from 85 women with severe endometriosis (rAFS stage III and IV) during laparoscopic surgery during the proliferative phase. Prior to surgery clinical data were collected. The concentrations of specific markers for endometriosis in the peritoneal fluid were determined using an ELISA and a comparison between peritoneal fluid markers in women using GnRHa and no hormonal treatment was performed using a non-parametric Mann-Whitney U test.ResultsThe study included peritoneal fluid from 39 patients who had been administered GnRHa (Zoladex®) in the three months prior to surgery and 46 from women with no hormonal treatment in this period. Concentrations of IL-8, PAPP-A, glycodelin-A and midkine were significantly reduced in the GnRHa treatment group compared to women receiving no hormonal treatment. RANTES, MCP-1, ENA-78, TNF-α, OPG, IP-10 and defensin showed no significant change between the two groups.ConclusionsGnRHa mediate a significant regression in the inflammatory nature of the peritoneal microenvironment in women with endometriosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Obstetrics & Gynecology and Reproductive Biology - Volume 170, Issue 2, October 2013, Pages 550-554
نویسندگان
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