‘On/off’-switchable catalysis by a smart enzyme-like imprinted polymer

‘On/off’-switchable catalysis by a smart enzyme-like imprinted polymer is reported. This unique imprinted polymer was composed of poly(N-isopropylacrylamide)-containing p-nitrophenyl phosphate-imprinted networks that exhibited temperature-dependent hydrophilicity/hydrophobicity. At a relatively low temperature (such as 20 °C), this polymer was capable of vigorous catalysis for the hydrolysis of p-nitrophenyl acetate due to its hydrophilic networks, which enabled access to the imprinted framework. On the contrary, at higher temperatures (such as 40 °C), this polymer demonstrated poor catalysis resulting from its dramatically increased hydrophobicity, which inhibited access to the imprinted sites. Unlike previously reported imprinted polymers which lack adjustable networks, this novel imprinted polymer employed thermosensitive poly(N-isopropylacrylamide) networks, thus enabling the switchable catalysis.

By creating a thermosensitive hydrophilic/hydrophobic transition within the imprinted networks, the prepared enzyme-like imprinted catalyst was capable of ‘yes/no’-regulated access to the reactants, leading to ‘on/off’-switchable catalysis..Figure optionsDownload high-quality image (57 K)Download as PowerPoint slideResearch highlights
► A smart MIP-S capable of ‘yes/no’-regulated access to the reactants was prepared.
► This regulated access enabled ‘on/off’-switchable catalysis.
► This smart MIP-S demonstrated vigorous catalysis at relatively low temperatures.
► However, this MIP-S showed poor reactivity at relatively high temperatures.