کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6182824 | 1254037 | 2014 | 8 صفحه PDF | دانلود رایگان |
Research highlights
- Prognostic importance of 18-F-FDG PET in endometrial cancer is reviewed.
- Pooled average SUVmax was higher in high risk patients vs. low risk ones.
- Pooled HR of pre-operative SUVmax for disease free survival was 7.415.
ObjectivesIn the current study, we systematically searched and analyzed the available literature on the prognostic value of semi-quantitative 18F-FDG PET imaging (SUVmax/mean) in patients with endometrial cancer and presenting the results in a meta-analytic format.MethodsPubmed, SCOPUS, and ISI Web of Knowledge were searched using “endometr* AND PET” as the search algorithm. All studies evaluating the 18F-FDG PET performance in pre-operative risk stratification or its prognostic value in patients with endometrial cancer were included. Statistical pooling of diagnostic accuracy indices was performed using random effects model. Cochrane Q test and I2 index were used for heterogeneity evaluation.ResultsTen studies (771 patients) were included in the systematic review. Pooled average SUVmax values in patients with risk factors [grade III, lymphovascular invasion (LVI), cervical invasion (CI), myometrial invasion (MI) â¥Â 50%] were statistically higher than those in patients without risk factors. Pooled HR of pre-operative SUVmax for disease free survival was 7.415 [2.892-19.432] (p = 0.000046).ConclusionDespite higher average SUVmax in the high-risk group compared to the low-risk group of patients with endometrial cancer, the usefulness of 18F-FDG PET SUVmax in classifying patients into pre-defined risk groups seems to be limited. However, pre-operative SUVmax of endometrial tumors seems to be an independent prognostic marker of recurrence and death. Further large multicenter studies with adequate follow-up are needed to confirm our findings.
Journal: Gynecologic Oncology - Volume 132, Issue 3, March 2014, Pages 669-676