کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6183711 1254111 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reviewing the molecular mechanisms which increase endometrial cancer (EC) risk in women with polycystic ovarian syndrome (PCOS): Time for paradigm shift?
ترجمه فارسی عنوان
بررسی مکانیسم های مولکولی که باعث افزایش خطر ابتلا به سرطان آندومتر در زنان مبتلا به سندرم تخمدان پلی کیستیک می شود؟ زمان تغییر پارادایم؟
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
چکیده انگلیسی


- The molecular mechanisms linking PCOS and endometrial cancer are inconclusive.
- Hyperinsulinaemia and hyperestrogenism herald to genes over-expression in the pathogenesis of both PCOS and endometrial cancer.
- A paradigm shift into '-omics' research would yield a better understanding of the linkage.

Endometrial cancer (EC) is the commonest gynaecological cancer in North American and European women. Even though it has been shown that women with polycystic ovary syndrome (PCOS) have a three-fold increase in the risk of developing EC compared to women without PCOS, the precise molecular mechanisms which increase EC risk in women with PCOS remain unclear. Clinical strategies to prevent EC in PCOS are therefore not well researched and understood. Although raised estrogen levels, hyperinsulinaemia and, reduced apoptosis have been suggested as potential mechanisms, there is a lack of clarity about how these factors and other factors may interact to increase EC risk in PCOS. This article reviews the literature, on the potential molecular links between PCOS and EC but argues for a paradigm shift, to a systems biology-based approach in future research into the molecular links between PCOS and EC. The potential challenges of a systems biology-based approach are outlined but not considered insurmountable.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gynecologic Oncology - Volume 131, Issue 2, November 2013, Pages 489-492
نویسندگان
, , , , ,