کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6187761 1600703 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Colony Stimulating Factors 1, 2, 3 and early pregnancy steps: from bench to bedside
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Colony Stimulating Factors 1, 2, 3 and early pregnancy steps: from bench to bedside
چکیده انگلیسی


- CSFs are localised at the maternal-foetal interface.
- CSFs promote placental development and differentiation.
- CSFs help uterine immune modulation to aid implantation.
- Recombinant GM-CSF promotes embryo development in vitro.
- Follicular G-CSF can be used as an oocyte biomarker.

Reproductive immunology applies general immunology principles to specialised targets, reproduction and development. The involvement of colony-stimulating factors (CSFs) in reproduction illustrates this. The CSF family includes CSF-1 or macrophage CSF (M-CSF), CSF-2 or granulocyte macrophage CSF (GM-CSF), and CSF-3 or granulocyte CSF (G-CSF). Each member has a specific localisation and timed expression in the reproductive tract with specific functions involving them in ovulation, embryo implantation, placentation and further embryonic development. They are used in reproductive medicine, either as biomarkers of oocyte quality and competence (follicular G-CSF), or to supplement embryo culture media with human recombinant GM-CSF, or they are used as an innovative therapy by using human recombinant G-CSF for infertile patients. Given fundamental considerations on CSFs and their strong implication in reproduction, this review aimed to detail the current knowledge for each member of the family to improve our understanding of their implication in the maternal-foetal cytokinic dialogue and in possibly preventing reproductive disorders.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Reproductive Immunology - Volume 109, June 2015, Pages 1-6
نویسندگان
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