کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6188439 1600712 2013 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Progesterone and threatened abortion: a randomized clinical trial on endocervical cytokine concentrations
ترجمه فارسی عنوان
پروژسترون و تهدید سقط جنین: یک کارآزمایی بالینی تصادفی بر روی غلظت سیتوکین اندوکرین
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
چکیده انگلیسی

The purpose of this study was to investigate the effect of vaginal progesterone on endocervical cytokine concentration in women at risk of threatened abortion. One hundred and sixty pregnant women with clinical symptoms of threatened abortion before the 20th week of pregnancy were randomly assigned to receive vaginal progesterone or placebo. Cervical fluids were collected and endocervical concentrations of different cytokines (IFNγ, TNFα, IL-8, IL-10 and IL-12) were analyzed before and one week after progesterone or placebo treatment. A significant decrease in IFNγ and increase in IL-10 in endocervical fluid was seen when the values were compared before and after progesterone treatment. However, there were no significant differences in pregnancy outcomes between the placebo and progesterone groups. We conclude that despite the failure of vaginal progesterone treatment to improve pregnancy outcomes, progesterone can induce a shift in the concentration of cytokines in endocervical secretions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Reproductive Immunology - Volume 98, Issues 1–2, June 2013, Pages 52-60
نویسندگان
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