کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6188491 | 1600698 | 2016 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Elevated systemic galectin-1 levels characterize HELLP syndrome
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کلمات کلیدی
ETVHELLPPlGFsFlt-1soluble fms-like tyrosine kinaseuNKhemolysis elevated liver enzymes and low plateletsPregnancy - بارداریExtravillous trophoblasts - تروفوبلاست های فوق العاده ایUterine natural killer cells - سلول های قاتل طبیعی رحمplacental growth factor - عامل رشد جفتAngiogenic factors - عوامل آنژیوژنیکGal-1 - گال-1Galectin-1 - گالکتین-1
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Elevated systemic galectin-1 levels characterize HELLP syndrome Elevated systemic galectin-1 levels characterize HELLP syndrome](/preview/png/6188491.png)
چکیده انگلیسی
Galectin-1 (gal-1), a member of a family of conserved β-galactoside-binding proteins, has been shown to exert a key role during gestation. Though gal-1 is expressed at higher levels in the placenta from HELLP patients, it is still poorly understood whether systemic gal-1 levels also differ in HELLP patients. In the present study, we evaluated the systemic expression of gal-1, together with the angiogenic factors, placental growth factor (PlGF) and soluble fms-like tyrosine kinase 1 (sFlt-1) in conjunction with HELLP syndrome severity. Systemic levels of gal-1 and sFlt-1 were elevated in patients with both early- and late-onset HELLP syndrome as compared to healthy controls. In contrast, peripheral PlGF levels were decreased in early- and late-onset HELLP. A positive correlation between systemic gal-1 levels and sFlt-1/PlGF ratios was found in early onset HELLP patients. Our results show that HELLP syndrome is associated with increased circulating levels of gal-1; integrating systemic gal-1 measurements into the diagnostic analyses of pregnant women may provide more effective prediction of HELLP syndrome development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Reproductive Immunology - Volume 114, April 2016, Pages 38-43
Journal: Journal of Reproductive Immunology - Volume 114, April 2016, Pages 38-43
نویسندگان
Annegret Schnabel, Sandra M. Blois, Peter Meint, Nancy Freitag, Wolfgang Ernst, Gabriela Barrientos, Melanie L. Conrad, Matthias Rose, Birgit Seelbach-Göbel,