کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6189253 1256962 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Environmental origins of congenital heart disease: The heart-placenta connection
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Environmental origins of congenital heart disease: The heart-placenta connection
چکیده انگلیسی

SummaryAlthough the mammalian embryo is well protected in the uterus, environmental chemicals, drugs, and maternal nutritional imbalances can interfere with regulatory pathways directing placental and embryonic development early in gestation. Embryonic cells are most susceptible to environmental influences during cellular specification and differentiation stages. Because biochemical differentiation precedes morphological outcome often by days, the period of susceptibility to environmental chemicals expectedly precedes visible morphogenic effects. The cellular mechanisms by which drugs and other environmental factors disrupt embryonic development and induce cardiac abnormalities have remained undefined.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Fetal and Neonatal Medicine - Volume 18, Issue 5, October 2013, Pages 245-250
نویسندگان
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