کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6196425 1602579 2016 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reactive gliosis in the adult zebrafish retina
ترجمه فارسی عنوان
گلیوز واکنشی در شبکیه چشم ماهیان سفیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی و میکروب شناسی (عمومی)
چکیده انگلیسی


- Zebrafish Müller glia exhibit reactive gliosis immediately following retinal injury.
- Müller glia then down-regulate the gliotic response and become stem cells.
- Inhibition of Müller glial cell cycle re-entry results in persistent reactive gliosis.
- Persistent gliosis results in a temporary increase in photoreceptor neuroprotection.
- Persistent gliosis results in inhibition of retinal regeneration.

In contrast to mammals, zebrafish posses the remarkable ability to regenerate retinal neurons. Damage to the zebrafish retina induces Müller glia to act as stem cells, generating retinal progenitors for regeneration. In contrast, injury in the mammalian retina results in Müller glial reactive gliosis, a characteristic gliotic response that is normally detrimental to vision. Understanding the signaling pathways that determine how Müller glia respond to injury is a critical step toward promoting regeneration in the mammalian retina. Here we report that zebrafish Müller glia exhibit signs of reactive gliosis even under normal regenerative conditions and that cell cycle inhibition increases this response. Persistently reactive Müller glia increase their neuroprotective functions, temporarily saving photoreceptors from a cytotoxic light lesion. However, the absence of a sustained proliferation response results in a significant inhibition of retinal regeneration. Interestingly, when cell cycle inhibition is released, a partial recovery of regeneration is observed. Together, these data demonstrate that zebrafish Müller glia possess both gliotic and regenerative potential.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Eye Research - Volume 143, February 2016, Pages 98-109
نویسندگان
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