کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6196507 1602577 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
OCT angiography in the mouse: A novel evaluation method for vascular pathologies of the mouse retina
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی و میکروب شناسی (عمومی)
پیش نمایش صفحه اول مقاله
OCT angiography in the mouse: A novel evaluation method for vascular pathologies of the mouse retina
چکیده انگلیسی


- We demonstrate the application of OCT angiography in the mouse retina.
- We visualize the normal vascular plexus in the different retinal layers.
- We visualize pathological vascularization in a mouse model of laser-induced CNV.

PurposeTo investigate the application of optical coherence tomography (OCT) angiography in the retinas of healthy mice and to evaluate choroidal neovascularization (CNV) in a mouse model of laser-induced CNV.MethodsC57BL/6J mice aged 18-25 weeks were examined using the spectral-domain optical coherence tomography device RTVue XR Avanti (Optovue, Inc, Fremont, California, USA). Blood flow in different retinal layers was detected using the split-spectrum amplitude-decorrelation angiography algorithm. Fluorescein angiography (FA) images were obtained using the Heidelberg Spectralis device (Heidelberg, Germany).ResultsUsing the RTVue XR Avanti, we were able to obtain high-quality OCT angiography images of normal vasculature in the superficial, deep capillary and choriocapillary layers in laser-treated mice and untreated controls. Whereas no blood flow was detectable in the outer retina of untreated mice, blood flow and hence neovascular vessels were found in laser-treated mice.ConclusionsOCT angiography can clearly visualize the normal vascular plexus in the different retinal layers in the mouse retina and choroid. With OCT angiography, it is possible to verify the choroidal neovascularization induced by laser treatment. Thus, OCT angiography is a helpful imaging tool for non-invasive, in vivo evaluation of laser-induced CNV in the mouse.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Eye Research - Volume 145, April 2016, Pages 417-423
نویسندگان
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