کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6203797 1263451 2010 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Gene profiling in experimental models of eye growth: Clues to myopia pathogenesis
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی سیستم های حسی
پیش نمایش صفحه اول مقاله
Gene profiling in experimental models of eye growth: Clues to myopia pathogenesis
چکیده انگلیسی

To understand the complex regulatory pathways that underlie the development of refractive errors, expression profiling has evaluated gene expression in ocular tissues of well-characterized experimental models that alter postnatal eye growth and induce refractive errors. Derived from a variety of platforms (e.g. differential display, spotted microarrays or Affymetrix GeneChips), gene expression patterns are now being identified in species that include chicken, mouse and primate. Reconciling available results is hindered by varied experimental designs and analytical/statistical features. Continued application of these methods offers promise to provide the much-needed mechanistic framework to develop therapies to normalize refractive development in children.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vision Research - Volume 50, Issue 23, 23 November 2010, Pages 2322-2333
نویسندگان
, ,