کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6203967 1603293 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Altered joint tribology in osteoarthritis: Reduced lubricin synthesis due to the inflammatory process. New horizons for therapeutic approaches
ترجمه فارسی عنوان
سندرم متابولیسم مفصلی در استئوآرتریت: کاهش سنتز لوبریتین به علت فرآیند التهابی. افق های جدید برای رویکردهای درمانی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی ارتوپدی، پزشکی ورزشی و توانبخشی
چکیده انگلیسی

Osteoarthritis (OA) is the most common form of joint disease. This review aimed to consolidate the current evidence that implicates the inflammatory process in the attenuation of synovial lubrication and joint tissue homeostasis in OA. Moreover, with these findings, we propose some evidence for novel therapeutic strategies for preventing and/or treating this complex disorder. The studies reviewed support that inflammatory mediators participate in the onset and progression of OA after joint injury. The flow of pro-inflammatory cytokines following an acute injury seems to be directly associated with altered lubricating ability in the joint tissue. The latter is associated with reduced level of lubricin, one of the major joint lubricants. Future research should focus on the development of new therapies that attenuate the inflammatory process and restore lubricin synthesis and function. This approach could support joint tribology and synovial lubrication leading to improved joint function and pain relief.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Annals of Physical and Rehabilitation Medicine - Volume 59, Issue 3, June 2016, Pages 149-156
نویسندگان
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