کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
620717 882503 2014 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Design of large-scale manufacturing of induced pluripotent stem cell derived cardiomyocytes
ترجمه فارسی عنوان
طراحی و ساخت مقیاس بزرگ تولید سلول های بنیادی مشتق شده از سلول های بنیادی مشتق شده از سلول های بنیادی
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی تصفیه و جداسازی
چکیده انگلیسی


• Scale-up of manufacture of cardiomyocytes from pluripotent stem cellsis described.
• The use of biomechatronic design methodology in combination with CAD is shown.
• User requirement criteria are systematically analyzed for most favourable design.

A new approach for design of large-scale manufacture of stem cell derived cells by using the biomechatronic methodology and computer-aided-design tools is described. The systematic conceptual design methodology for systems composed of active mechanical, electronic and biological components, here referred to as biomechatronics, is combined with the methodology for computer-aided design of bioprocesses. The objective has been to systematically investigate and compare by the combination of the methodologies what are favourable design alternatives in terms of equipment configuration and economic parameters. A demonstration case has been used for the manufacture of cardiomyocytes from human induced pluripotent stem cells. The results show how certain configurations are more favourable than others under given boundary conditions. The study indicates that the approach is possible to apply on other related bio-manufacturing systems.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemical Engineering Research and Design - Volume 92, Issue 6, June 2014, Pages 1142–1152
نویسندگان
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