کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6208468 1603975 2016 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Topical Tranexamic Acid May Improve Early Functional Outcomes of Primary Total Knee Arthroplasty
ترجمه فارسی عنوان
اسید تاناکونیک اسامی موضعی می تواند نتایج عملکرد اولیه آرتروپلاستی زانو را بهبود بخشد
کلمات کلیدی
آرتروپلاستی کل زانو، اسید تانونکامیک موضعی، نتیجه اولیه، تابع، انتقال خون،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی ارتوپدی، پزشکی ورزشی و توانبخشی
چکیده انگلیسی

IntroductionThe use of tranexamic acid (TXA) reduces postoperative anemia and blood transfusion requirements. We investigated if these beneficial effects improve the early outcomes of primary total knee arthroplasty (TKA).MethodsWe retrospectively studied 166 consecutive patients (179 TKAs) who received topical TXA (3 g before tourniquet deflation). This “study group” was compared with a “control group” of 197 consecutive patients (209 TKAs) in whom no TXA was used. We captured outcomes during the first 4 postoperative months. Knee Society score (KSS) was determined preoperatively, 6 weeks, and 4 months postoperatively. The outcomes were compared using univariate analysis. Multiple logistic regressions were calculated to assess differences between groups in KSS at 6 weeks and 4 months, controlling for age, sex, body mass index, and preoperative KSS.ResultsPostoperative hemoglobin was significantly higher in the study than that in the control group on day 1, day 2, and at discharge (P < .0001). Blood transfusions were required in 5% and 22% of patients (P < .001), respectively. Six weeks postoperatively, the functional KSS and its 5 categories (ability to walk, negotiate stairs up and down, stand up from a chair, and the use of support) were significantly higher in the study than those in the control group (P ≤ .001). Four months postoperatively, there was no difference in the KSS between the groups.DiscussionOur study suggests that the clinical benefit of topical TXA administration extends beyond the hospitalization period. Its use may improve knee function during the first 6 postoperative weeks. This beneficial clinical effect seems to be negligible afterward.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Arthroplasty - Volume 31, Issue 7, July 2016, Pages 1449-1452
نویسندگان
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