کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6209064 | 1603987 | 2015 | 5 صفحه PDF | دانلود رایگان |
The aim of this trial was to evaluate the efficacy and safety of intra-articular administration of tranexamic acid (TXA) plus diluted-epinephrine (DEP) on perioperative blood loss and transfusion in primary unilateral total knee arthroplasty (TKA) without drainage. One hundred patients scheduled to undergo TKA were randomized into two groups: 50 patients received intra-articular 3Â g TXA plus 0.25Â mg DEP (1:200,000), and 50 patients received 3Â g topical TXA alone. The results showed that topical combined administration significantly reduced total blood loss (PÂ =Â 0.006), hidden blood loss (PÂ =Â 0.000) and transfusion rate (0% vs. 4%), without increasing the risk of thromboembolic and hemodynamic complications (PÂ >Â 0.05). Therefore, topical TXA plus DEP was effective and safe in reducing blood loss and transfusion following TKA, without substantial complications.
Journal: The Journal of Arthroplasty - Volume 30, Issue 8, August 2015, Pages 1354-1358