کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
621297 | 882546 | 2010 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Operation design for controlling polymorphism in the anti-solvent crystallization by using ternary phase diagram
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
تصفیه و جداسازی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In the pharmaceutical production, to control polymorph formation is important from the viewpoint of the productivity and the bioavailability. Anti-solvent or drowning-out crystallization is widely used in the pharmaceutical industry for high yield production. However, anti-solvent addition method to control polymorph formation in anti-solvent crystallization has not been discussed enough. In this study, indomethacin (IMC) which has three polymorphs was used. The purpose of this study is to establish a production method of the target polymorph in the anti-solvent crystallization (IMC-acetone-heptane system). The simulation model for determination of anti-solvent feed rate based on the ternary phase diagram was proposed. The stability of the polymorph of IMC crystal in the solution was changed not only with temperature but also with composition of the mixed solvent. From the experimental and simulation results, the design strategy of anti-solvent crystallization was proposed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemical Engineering Research and Design - Volume 88, Issue 9, September 2010, Pages 1242-1247
Journal: Chemical Engineering Research and Design - Volume 88, Issue 9, September 2010, Pages 1242-1247
نویسندگان
Hiroshi Takiyama, Takuma Minamisono, Yohei Osada, Masakuni Matsuoka,