کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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621427 | 882554 | 2010 | 10 صفحه PDF | دانلود رایگان |

Protein crystallisation is known to be affected by many factors and inherently difficult to control. Being able to model the crystal growth behaviour, especially at process scale for the population of particles in a crystalliser will no doubt greatly help the formulation and controlled manufacture of protein crystals. In this paper, a morphological population balance model for crystallisation of tetragonal Hen-Egg-White (HEW) lysozyme is presented. Since the population balance model has incorporated crystal shape information, it is able to simulate the dynamic evolution of the shape distribution as well as size distribution. The morphological population balance model requires faceted growth kinetics data, which was obtained from published data in literature for the two identified independent crystallographic faces, {1 0 1} and {1 1 0}, of HEW lysozyme crystals.
Journal: Chemical Engineering Research and Design - Volume 88, Issue 4, April 2010, Pages 437–446