کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6215387 1606653 2016 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sequential development of hepatocellular carcinoma and liver angiosarcoma in a vinyl chloride-exposed worker
ترجمه فارسی عنوان
توسعه متوالی کارسینوم سلول های بنیادی و آنژیوارسکوما کبدی در یک کارگر وینیل کلراید
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی آسیب‌شناسی و فناوری پزشکی
چکیده انگلیسی

SummaryStrong experimental and clinical evidences have definitely linked occupational vinyl chloride exposure to development of angiosarcoma of the liver. In contrast, despite the International Agency for Research on Cancer having included vinyl chloride among the causes of hepatocellular carcinoma, the association between vinyl chloride exposure and hepatocellular carcinoma remains debated. This issue is relevant, because occupational exposure to high levels of vinyl chloride may still occur. We report a unique case of sequential occurrences of hepatocellular carcinoma and angiosarcoma of the liver, in a vinyl chloride-exposed worker without cirrhosis and any known risk factor for chronic liver disease. Both the hepatocellular carcinoma and the surrounding normal liver showed micronucleus formation, which reflects genotoxic effect of vinyl chloride. Angiosarcoma showed a KRAS G12D point mutation, which is considered to be characteristic of vinyl chloride-induced angiosarcoma. This case supports the pathogenic role of vinyl chloride in both hepatocellular carcinoma and angiosarcoma development.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Pathology - Volume 57, November 2016, Pages 193-196
نویسندگان
, , , , , , ,