کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6216799 1273738 2014 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A novel scoring system to predict the development of necrotizing enterocolitis totalis in premature infants
ترجمه فارسی عنوان
یک سیستم نمره دهی جدید برای پیش بینی توسعه انتروکولیت نکتروز در نوزادان نارس
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پریناتولوژی (پزشکی مادر و جنین)، طب اطفال و بهداشت کودک
چکیده انگلیسی

Background/PurposeNecrotizing enterocolitis totalis (NEC-totalis) is the severest form of NEC, with mortality rate of almost 100% even in the busiest neonatal centers. Despite such a prognosis, its risk factors remain elusive. We seek to identify clinical and laboratory parameters that differentiate NEC-totalis from NEC, and to use these factors to develop a scoring system to identify patients at risk for NEC-totalis upon presentation.MethodNEC patients were identified from our electronic medical record using ICD9 code. Diagnosis of NEC-totalis was based on operative and autopsy reports. Patients were divided into 2 groups: NEC-but-no-totalis and NEC-totalis. Clinical/laboratory data were obtained for each group. T-test, multivariate logistic regression and backward stepwise regression analysis were performed to identify risk factors for NEC-totalis and these risk factors were formulated into a “Totalis Score.”ResultAmong 157 NEC patients, 13 had NEC-totalis. NEC-totalis patients, compared to NEC alone, had fewer platelets, older age at diagnosis of NEC and greater phosphorus and creatinine levels. A 0-5 point scale “Totalis Score” based on these risk factors had sensitivity of 92% and a specificity of 78% for the diagnosis of NEC-totalis.ConclusionLow platelet, high phosphorus, high creatinine and older age at diagnosis of NEC were associated with a greater risk of developing NEC-totalis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pediatric Surgery - Volume 49, Issue 7, July 2014, Pages 1053-1056
نویسندگان
, , , ,