کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6218439 1274280 2013 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The antifibrotic drug halofuginone reduces ischemia/reperfusion-induced oxidative renal damage in rats
ترجمه فارسی عنوان
هالوفوگینون داروهای ضد انتی فوتی باعث کاهش آسیب اکسیداتیو ناشی از ایسکمی / رپرفوسی در موش صحرایی می شود
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پریناتولوژی (پزشکی مادر و جنین)، طب اطفال و بهداشت کودک
چکیده انگلیسی

AimThe objective of the present study was to evaluate the protective effects of halofuginone against renal ischemia/reperfusion (I/R) injury.Materials and methodsMale Wistar albino rats were unilaterally nephrectomized and the left renal pedicles were occluded for 45 min to induce ischemia and then reperfused for 6 h (early) or for 72 h (late). The rats were treated intraperitoneally with either halofuginone (100 μg/kg/day) or saline 30 min prior to ischemia and the dose was repeated in the late reperfusion groups. In the sham groups, rats underwent unilateral nephrectomy and were treated at similar time points. The animals were decapitated at either 6 h or 72 h of reperfusion and trunk blood and kidney samples were obtained.ResultsI/R injury increased renal malondialdehyde levels, myeloperoxidase activity and reactive oxygen radical levels, and decreased the renal glutathione content. Halofuginone treatment was found to reduce oxidative I/R injury and improve renal function in the rat kidney, as evidenced by reduced generation of reactive oxygen species, depressed lipid peroxidation and myeloperoxidase activity, and increased glutathione levels.ConclusionsThe present findings demonstrate the anti-inflammatory and antioxidant effects of halofuginone in renal I/R injury, supporting its potential use where renal I/R injury is inevitable.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pediatric Urology - Volume 9, Issue 2, April 2013, Pages 174-183
نویسندگان
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