کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6218490 1274281 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Intravesical botulinum type-A toxin (Dysport®) in the treatment of idiopathic detrusor overactivity in children
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پریناتولوژی (پزشکی مادر و جنین)، طب اطفال و بهداشت کودک
پیش نمایش صفحه اول مقاله
Intravesical botulinum type-A toxin (Dysport®) in the treatment of idiopathic detrusor overactivity in children
چکیده انگلیسی

ObjectiveBotulinum type-A toxin is increasingly used for refractory idiopathic detrusor overactivity (IDO) in children. We reviewed our experience and sought to ascertain the influence of dose and functional bladder capacity on outcome.Patients and methodsThirty patients, aged 6-16 years, with urodynamically proven IDO, had intravesical injections of 400-500 iu of Dysport®. Outcome was assessed clinically at least 5 months after the injection.ResultsData were available for 27 patients. Urinary frequency was improved in 10; nocturia was improved in 7. Urgency resolved in 10 patients and urge incontinence in 12 (44%). Complications reported were UTI (7), urinary retention (1) and bladder pain (1).The dose of Dysport® used was not significantly higher (14 iu/kg v 13 iu/kg) in patients dry at follow up than in those who remained wet (p = 0.45). Functional bladder capacity was not significantly different in patients dry after treatment (p = 0.82).ConclusionThis retrospective study demonstrates similar response to a single treatment with intravesical Botulinum type-A toxin to previous series. We did not demonstrate a correlation between dose or functional bladder capacity and resolution of incontinence. A multi-centre study is required to further investigate this promising treatment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pediatric Urology - Volume 9, Issue 6, Part A, December 2013, Pages 750-753
نویسندگان
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