Delayed release matrix pellet preparation containing an alkalizing pore-former agent

▶ The aim of this study was to develop a delayed release matrix pellet containing atenolol as active pharmaceutical ingredient and to increase the bioavailability of the product. ▶ The matrix pellet additionally contained trisodium phosphate dodecahydrate as alkalizing pore-former agent to enhance the dissolution of the API at pH 6.8. ▶ The delayed release was ensured by coating with a gastroresistant polymer.