کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6220992 | 1607439 | 2015 | 9 صفحه PDF | دانلود رایگان |
ObjectivesTo evaluate the epidemiology of perineal streptococcal infection and recurrence rates following amoxicillin treatment.Study designWe used laboratory logs in a single pediatric practice to identify patients 0-18Â years of age with perineal cultures positive for group A Streptococcus (GAS) and reviewed their medical charts. We described epidemiologic features, determined recurrence rates following antibiotic treatment, and performed a case-control study to identify possible risk factors for recurrence in patients treated with amoxicillin.ResultsWe found a perineal streptococcal infection rate of 4.6 per 10â000 patient encounters and a recurrence rate in 157 patients with perineal streptococcal infection of 12.4% after amoxicillin. In male patients, the predominant site of involvement was the perianal region (86%), and for female patients, the perivaginal area (62%). Nearly 80% of patients were 2-7Â years of age (range 18 days-12.5Â years). Perineal streptococcal infection and GAS pharyngitis followed a similar seasonal pattern of occurrence with 65% of perineal streptococcal infection occurring October through March. In patients with perineal streptococcal infection, 95% had a concomitant pharyngeal culture positive for GAS. Best predictive factors for recurrence after amoxicillin were longer duration of symptoms prior to diagnosis and having a sibling with perineal streptococcal infection at some time before or after the initial episode.ConclusionsFollowing treatment with amoxicillin, we found a low recurrence rate of 12.4%. Amoxicillin can be expected to be reliable first-line therapy for perineal streptococcal infection.
Journal: The Journal of Pediatrics - Volume 167, Issue 3, September 2015, Pages 687-693.e2