کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6221143 1607443 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Safety of Deep Sedation in Young Children with Sickle Cell Disease: A Retrospective Cohort Study
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پریناتولوژی (پزشکی مادر و جنین)، طب اطفال و بهداشت کودک
پیش نمایش صفحه اول مقاله
Safety of Deep Sedation in Young Children with Sickle Cell Disease: A Retrospective Cohort Study
چکیده انگلیسی

ObjectiveTo assess the rates and types of complications associated with deep sedation in children with sickle cell disease (SCD) and to explore potential risk factors.Study designThis was a retrospective cohort study of children with SCD and a comparison group of children without SCD who underwent magnetic resonance imaging with deep sedation. The rates of general and SCD-associated sedation complications were calculated, and potential associated clinical and laboratory variables were assessed.ResultsA total of 162 sedation records in 94 subjects with SCD and 324 sedation records in 321 subjects without SCD were assessed (mean age, 4.3 years in both groups). Pentobarbital, fentanyl, and midazolam were used in the majority of sedation episodes without routine presedation transfusion. Sedation-related complication rates did not differ significantly between the SCD and comparison groups. Within 1 month after the sedation procedure, 17 children (10%) experienced a vaso-occlusive pain episode (VOE), and 2 children (1.2%) developed acute chest syndrome. Preprocedure and postprocedure rates of these complications did not differ significantly. Subjects who developed VOE after sedation had a significantly higher VOE rate before sedation, but no other significant clinical or laboratory risk factors were identified.ConclusionDeep sedation in young children with SCD using a standard protocol is safe, with a sedation-related complication rate comparable to that of the general pediatric population. The observed rate of VOE, although not significantly higher than expected, warrants further investigation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Pediatrics - Volume 166, Issue 5, May 2015, Pages 1226-1232
نویسندگان
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