کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6221512 | 1607444 | 2015 | 14 صفحه PDF | دانلود رایگان |
ObjectiveTo assess adolescent and young adult determinants of visceral adipose tissue (VAT) at ages 26-28Â years.Study designProspective study (ages 9-28Â years) of cardiometabolic measures, menarche age, menses irregularities, metabolic syndrome, impaired fasting glucose-type 2 diabetes mellitus, and VAT in 400 girls (248 black, 152 white).ResultsAdolescent (age 14-19) independent variables for greater VAT at ages 26-28 included larger mean waist circumference (partial R2Â =Â 30.8%), earlier age at menarche (0.9%), and white race (1.8%). Young adult (ages 20-28Â years) independent variables for greater VAT included larger mean waist circumference (partial R2Â =Â 61.7%), greater triglyceride levels (3.3%), lower high-density lipoprotein cholesterol (1.0%), and greater insulin resistance (homeostasis model assessment-estimated insulin resistance; 0.4%). Independent variables for greater VAT when both adolescent and young adult variables were used included waist (tertile rank change from adolescence to young adulthood, partial R2Â =Â 58.3%), greater young adult triglyceride levels (4.4%), white race (1.8%), greater young adult homeostasis model assessment-estimated insulin resistance (age 20-28, 2.4%), and earlier menarche age (0.7%). Menses irregularities were not independently associated with young adult VAT.ConclusionsAdolescent girls with early menarche and larger waist circumference should be targets for primary prevention of accretion of VAT. In young adulthood, VAT is associated with dysregulated cardiometabolic profiles, which is greater for those with waist circumference increases from adolescence to adulthood. Waist circumference during young adulthood, and to a lesser degree during adolescence, is an inexpensive surrogate for VAT at ages 26-28 years.
Journal: The Journal of Pediatrics - Volume 166, Issue 4, April 2015, Pages 936-946.e3